| Bioactivity | PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM). PARP1-IN-33 has retinal cytoprotective effect, with an EC50 of 0.02 nM (inhibition on MTS activity of H2O2 induced human retinal pigment epithelial cell)[1]. |
| Invitro | PARP1-IN-33 对过氧化氢引起的视网膜细胞损伤有很强的保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PARP1-IN-33 相关抗体: Cell Viability Assay [1] Cell Line: |
| CAS | 2640677-68-3 |
| Formula | C23H24ClFN4O |
| Molar Mass | 426.91 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. 김은희, et al. Isoquinolinone derivative, preparation method therefor, and pharmaceutical composition, comprising same as active ingredient, for prevention or treatment of poly(adp-ribose)polymerase-1 (parp-1)-associated disease, WO2021086077, WPO, 2021-05-06. |
PARP1-IN-33
CAS: 2640677-68-3 F: C23H24ClFN4O W: 426.91
PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM). PARP1-IN-33 has retinal cytoprotective effect, with an EC5
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