| Bioactivity | PARP1-IN-17 is a PARP-1 inhibitor (IC50 = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity[1]. |
| Invitro | PARP1-IN-17 (Compound 11b) (72 小时) 对 A549 细胞，OVCAR-3 细胞，HCT-116 细胞和 MCF-7 细胞具有抑制增殖作用[1]。PARP1-IN-17 (1-4 μM, 48 h) 可减少 PAR 的生物合成，诱导 A549 细胞凋亡[1]。 0 --> PARP1-IN-17 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Name | PARP1-IN-17 |
| Formula | C24H27FN4O |
| Molar Mass | 406.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu L, et al. Discovery of novel 2, 3, 4, 5-tetrahydrospiro [benzo [c] azepine-1, 1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors [J]. BMC chemistry, 2023, 17(1): 147. |