| Bioactivity | PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1]. |
| Invitro | PARP1-IN-14 (compound 19k) 显著抑制耐药 Capan-1 细胞的增殖 (IC50 .PARP1-IN-14（0-1 μM，0-48 小时）可诱导亲代细胞和耐药细胞的细胞周期停滞和凋亡[1]。 0 --> PARP1-IN-14 相关抗体: |
| Name | PARP1-IN-14 |
| CAS | 2098639-70-2 |
| Formula | C28H24FN7O3 |
| Molar Mass | 525.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang P, et al. Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities. Eur J Med Chem. 2023 Nov 5;259:115709. |
PARP1-IN-14
CAS: 2098639-70-2 F: C28H24FN7O3 W: 525.53
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiprolifer
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