| Bioactivity | PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) [1]. |
| Invitro | PARP1-IN-10 (compound 12c) (10 μM, 48 h) shows no cytotoxic effects against NCI-60 human tumor cell lines[1].PARP1-IN-10 inhibits MDA-MB-436 cell line with an IC50 value of 3.73 μM[1].PARP1-IN-10 (1 and 3.73 μM, 48 h) causes cell cyle arrest at G2/M with dose-dependent manner[1].PARP1-IN-10 (0.5 μM, 48 h) shows antiprolifetative effect of temozolomide (TMZ) about 7 times (IC50 = 3.64 μM) in A549 cell line compared to TMZ alone (IC50=24.2 μM)[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | PARP1-IN-10 |
| CAS | 2494001-21-5 |
| Formula | C20H23N3O5 |
| Molar Mass | 385.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
PARP1-IN-10
CAS: 2494001-21-5 F: C20H23N3O5 W: 385.41
PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP
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