| Bioactivity | PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma[1]. |
| Target | IC50: 302 μM (PARP-1) |
| Invitro | PARP-1-IN-4 对 PARP-1 具有抑制活性，IC50 值为 302 μM[1]。PARP-1-IN-4 (0.1, 1 and 10 μM; 24h and 48h) 对 A549 细胞具有细胞毒性[1]。PARP-1-IN-4 (1 μM; 24h) 显著增加 caspase-3 和 caspase-9 蛋白的表达水平[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | PARP-1-IN-4 |
| CAS | 684234-56-8 |
| Formula | C22H15Cl2N3O2 |
| Molar Mass | 424.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456. |
PARP-1-IN-4
CAS: 684234-56-8 F: C22H15Cl2N3O2 W: 424.28
PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1
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