| Bioactivity | PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1]. |
| Target | Kd: 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases. |
| Name | PAN endonuclease-IN-1 |
| CAS | 2378640-67-4 |
| Formula | C14H8F3N5O4 |
| Molar Mass | 367.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alysia J Kohlbrand, et al. Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry. 2024 Jan 8. |
PAN endonuclease-IN-1
CAS: 2378640-67-4 F: C14H8F3N5O4 W: 367.24
PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328
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