PACAP (1-38) free acid TFA

CAS: F: C205H331F3N62O56S W: 4649.26

PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility

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Bioactivity	PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1[1][2].
Invitro	PACAP (1-38) free acid TFA (1 nM) 增加 P 物质、胃泌素释放肽和血管活性肠肽的释放[1]。PACAP (1-38) free acid TFA (100 nM; 10 min) 诱导大鼠海马切片中 NR2B 的酪氨酸磷酸化[2]。 Western Blot Analysis[2] Cell Line:
Name	PACAP (1-38) free acid TFA
Sequence	His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys
Shortening	HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
Formula	C205H331F3N62O56S
Molar Mass	4649.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tornøe K, et al. PACAP 1-38 as neurotransmitter in the porcine antrum. Regul Pept. 2001 Sep 15;101(1-3):109-21. [2]. Yaka R, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003 Mar 14;278(11):9630-8.