| Bioactivity | PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively[1]. |
| CAS | 1620951-72-5 |
| Formula | C18H16ClN9O |
| Molar Mass | 409.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Matthias Schönberger, et al. Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat Chem. 2014 Aug;6(8):712-9. |