| Bioactivity | P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1]. | |||||||||
| Target | mitophagy. | |||||||||
| Invitro | P62-mediated mitophagy inducer (10 µM; 0, 1, 3, 6, 24 h) stabilizes Nrf2 and (10 µM; 9 h) upregulates P62 expression activating mitophagy[1].P62-mediated mitophagy (10 µM; 24 h) acts downstream of the PINK1/Parkin signaling pathway in MEFs[1].P62-mediated mitophagy inducer positively affects mitochondrial poly-ubiquitination and coupling[1]. RT-PCR[1] Cell Line: | |||||||||
| Name | P62-mediated mitophagy inducer | |||||||||
| CAS | 1809031-84-2 | |||||||||
| Formula | C14H9IN4O2 | |||||||||
| Molar Mass | 392.15 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96. |
P62-mediated mitophagy inducer
CAS: 1809031-84-2 F: C14H9IN4O2 W: 392.15
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mit
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