| Bioactivity | P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity (Blue: E3 ligase ligand (HY-162945); Pink: target protein ligand (HY-162946); Black: linker (HY-162947))[1]. |
| Formula | C135H189N33O27S3 |
| Molar Mass | 2802.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang B, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129945. |