| Bioactivity | P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2]. |
| CAS | 1359627-33-0 |
| Formula | C15H17N5O3 |
| Molar Mass | 315.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293(3): 931-940. [2]. Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11(4):e0527922. |
P516-0475
CAS: 1359627-33-0 F: C15H17N5O3 W: 315.33
P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system wi
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