P2Y2R/GPR17 antagonist 1_product_DataBase

CAS: 2395016-49-4 F: C19H13ClN2O6S W: 432.83

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM a

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].

Target

IC50: 1.67 µM (GPR17), 3.17 µM (P2Y2R)

Name

P2Y2R/GPR17 antagonist 1

CAS

2395016-49-4

Formula

C19H13ClN2O6S

Molar Mass

432.83

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.

PeptideDB

P2Y2R/GPR17 antagonist 1

CAS: 2395016-49-4 F: C19H13ClN2O6S W: 432.83