| Bioactivity | P2Y14R antagonist 2 (compound 39) is a potent, selective and orally active P2Y14R antagonist with an IC50 value of 0.40 nM. P2Y14R antagonist 2 shows anti-inflammatory activity. P2Y14R antagonist 2 has the potential for the research of colitis[1]. |
| In Vivo | P2Y14R antagonist 2 (50, 100 µM for 100µL per mice; rectally administered, daily for 7 days) 对患有结肠炎的小鼠表现出抗炎活性[1]。药代动力学分析[1].Parameters |
| CAS | 2989271-65-8 |
| Formula | C18H13FN2O4S |
| Molar Mass | 372.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang YH, et al. Discovery of a Series of 4-Amide-thiophene-2-carboxyl Derivatives as Highly Potent P2Y14 Receptor Antagonists for Inflammatory Bowel Disease Treatment. J Med Chem. 2024 Jul 3. |
P2Y14R antagonist 2
CAS: 2989271-65-8 F: C18H13FN2O4S W: 372.37
P2Y14R antagonist 2 (compound 39) is a potent, selective and orally active P2Y14R antagonist with an IC50 value of 0.40
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