| Bioactivity | P2X7 receptor antagonist-4 (Compound 14a) is a P2X7R antagonist. The P2X7 receptor antagonist-4 values of P2X7R IC50 in human and mouse are 64.7 and 10.1 nM, respectively. P2X7 receptor antagonist-4 can inhibit the activation of NLRP3 inflammasome, thereby inhibiting the expression of caspase-1, gasdermin D, IL-1β and IL-18 in the damaged kidney of sepsis mice[1]. |
| Target | P2X7 Receptor Antagonist,exerted a therapeutic potential against septic acute kidney injury(AKI). human and mouse P2X7R IC50 values of 64.7 and 10.1 nM.;https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00837 (Compd 14a);新品上线，张雨新分子推荐20230901 |
| Name | P2X7 receptor antagonist-4 |
| Formula | C19H15BrN6O3S2 |
| Molar Mass | 519.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang R, et al. Design, Synthesis, and Biological Evaluation of Novel P2X7 Receptor Antagonists for the Treatment of Septic Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11365-11389. |
P2X7 receptor antagonist-4
CAS: F: C19H15BrN6O3S2 W: 519.39
P2X7 receptor antagonist-4 (Compound 14a) is a P2X7R antagonist. The P2X7 receptor antagonist-4 values of P2X7R IC50 in
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.