| Bioactivity | P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration[1]. |
| Invitro | P163-0892 (0-32 μg/mL; 48 h) shows antifungal activity with a MIC of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively[1].P163-0892 has good aqueous solubility[1].P163-0892 has no cytotoxicity and no obvious cardiotoxicity[1]. |
| In Vivo | P163-0892 (10 mg/kg; 5 days) significantly extends the survival of larvae infected with either C. neoformans or C. gattii[1]. Animal Model: |
| Name | P163-0892 |
| CAS | 1574576-45-6 |
| Formula | C19H20N2O3S |
| Molar Mass | 356.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li L, et al. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. J Med Chem. 2022 Aug 3. |
P163-0892
CAS: 1574576-45-6 F: C19H20N2O3S W: 356.44
P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium
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