Bioactivity | P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1[1]. |
In Vivo | P110在多种人类疾病的动物模型中表现出巨大益处,但由于P110对血清和细胞蛋白酶敏感,且不能通过口服方式吸收,因此将其转化为临床干预受到限制。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
CAS | 1411976-18-5 |
Sequence | Asp-Leu-Leu-Pro-Arg-Gly-Ser |
Shortening | DLLPRGS |
Formula | C32H56N10O11 |
Molar Mass | 756.85 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Luis Rios, et al. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356. |