| Bioactivity | P-gp inhibitor 27 (Compound D2) is an inhibitor for P-glycoprotein (P-gp), that downregulates the expression of P-gp and MRP1, increases the Rh123 accumulation in A2780/T cell, and reverses multidrug resistance to Paclitaxel (HY-B0015) (EC50 is 88 nM) and Cisplatin (HY-17394)[1]. |
| Formula | C25H25N3O4 |
| Molar Mass | 431.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peng YY, et al., Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi-drug resistance. Eur J Med Chem. 2025 Jan 15;282:117090. |