P-gp inhibitor 22_product_DataBase

Bioactivity	P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase[1].
Invitro	P-gp inhibitor 22（compound 4b；6.25-100 μM；24 小时）对 MCF-7/ADR 细胞具有显着的活性[1]。P-gp inhibitor 22（compound 4b；5 μM；24 小时）可诱导 MCF-7/ADR 细胞凋亡，并在 S 期积累[1]。P-gp inhibitor 22 抑制多种细胞系，如 PC-3、SKOV-3、HeLa、MCF-7/ADR、HFL-1 和 WI-38 细胞，IC50 值分别为 3.3 μM、0.7 μM、2.4 μM、5.0 μM、72.0 μM 和 61.1 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> P-gp inhibitor 22 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	1226674-74-3
Formula	C20H13ClN2O2
Molar Mass	348.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ashraf H F Abd El-Wahab, et al. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Sci Rep. 2024 Mar 31;14(1):7589.

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