| Bioactivity | P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs)[1]. |
| Target | IC50: 60.50 nM (H+/K+-ATPase) |
| In Vivo | P-CAB agent 1 has acceptable oral absorption in rats[1].Pharmacokinetic Parameters of P-CAB agent 1 in female Sprague-Dawley rats[1]. |
| Name | P-CAB agent 1 |
| CAS | 2374139-68-9 |
| Formula | C26H23FN4O |
| Molar Mass | 426.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang X, et al. Design, synthesis and biological evaluation of novel 5-methyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives as potent potassium-competitive acid blockers. Bioorg Med Chem. 2022 Jun 15;64:116765. |
P-CAB agent 1
CAS: 2374139-68-9 F: C26H23FN4O W: 426.49
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM
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