| Bioactivity | Oxytocin antiparallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin[1][2]. | ||||||
| Invitro | 催产素和脱氨基催产素的平行和反平行、同质/异质双胱氨酸二聚体的生物活性为催产素的 0.2%-6%[1]。 | ||||||
| In Vivo | Oxytocin dimer (静脉注射；单剂量) 对大鼠的急性毒性小于催产素 (LD50=43 mg/kg vs 25 mg/kg)[2]。 | ||||||
| Name | Oxytocin antiparallel dimer | ||||||
| CAS | 20054-93-7 | ||||||
| Shortening | Sequence 1:CYIQNCPLG-NH2;Sequence 2:CYIQNCPLG-NH2 (Disulfide bridge:Chain1 Cys1 to Chain2 Cys6;Chain1 Cys6 to Chain2 Cys1) | ||||||
| Formula | C86H132N24O24S4 | ||||||
| Molar Mass | 2014.37 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Chen L, et al. Syntheses and biological activities of parallel and antiparallel homo and hetero bis-cystine dimers of oxytocin and deamino-oxytocin. Pept Res. 1996;9(3):114-121. [2]. Berde B, et al. Some pharmacological properties of oxytocin-dimers (α+ β)[J]. Experientia, 1971, 27: 1304-1305. |
Oxytocin antiparallel dimer
CAS: 20054-93-7 F: C86H132N24O24S4 W: 2014.37
Oxytocin antiparallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-lik
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