Oxprenolol hydrochloride_product_DataBase

Bioactivity	Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].
Invitro	Oxprenolol is lipophilic[3].Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin[3].
In Vivo	Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade[2]. Animal Model:
Name	Oxprenolol hydrochloride
CAS	6452-73-9
Formula	C15H24ClNO3
Molar Mass	301.81
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. T Nagatomo, et al. Binding Characteristics of 3H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [3]. Modamio P, et al. A comparative in vitro study of percutaneous penetration of β-blockers in human skin. International journal of pharmaceutics, 2000, 194(2): 249-259.

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