Oxantel_product_DataBase

Bioactivity	Oxantel (CP-14445), a m-oxyphenol derivative of Pyrantel (HY-12641), is a N-subtype AChR agonist. Oxantel is an anthelmintic, with excellent trichuricidal properties[1][2].
Target	nAChR
Invitro	Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of T. muris[1]. Cell Viability Assay Cell Line:
In Vivo	Oxantel (1-10 mg/kg; i.p.) displays a high activity against T. muris in vivo, with an EC50 of 4.71 mg/kg[1].Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1]. Animal Model:
Name	Oxantel
CAS	36531-26-7
Formula	C13H16N2O
Molar Mass	216.28
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Richard J Martin, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [2]. V M Dale, et al. Oxantel-activated single channel currents in the muscle membrane of Ascaris suum. Parasitology. 1995 May;110 ( Pt 4):437-48.

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