| Bioactivity | Ouabain is a cardiac glycoside possessing cytotoxicity and anti-apoptotic effects. Ouabain is also an inhibitor of Na+/K+-ATPase. Additionally, Ouabain can act as a biological inductor, triggering regular and low-frequency oscillations of intracellular calcium ions ([Ca2+]i), which in turn may activate the transcription factor NF-κB[1][2]. |
| CAS | 630-60-4 |
| Formula | C29H44O12 |
| Molar Mass | 584.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aizman O, et al. Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13420-4. [2]. Lopina OD, et al. Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression. Front Physiol. 2020 Sep 4;11:1060. |