Osteostatin

CAS: 138949-73-2 F: C27H41N9O8 W: 619.67

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of

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Bioactivity	Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].
Invitro	Osteostatin (100，250，500 nM，7-9 天) 以浓度依赖的方式降低破骨细胞的分化[2]。Osteostatin (100，250，500 nM，7 天) 降低组织蛋白酶 K、破骨细胞相关 Ig 样受体 (OSCAR) 和NFATc1 的 mRNA 水平[2]。Osteostatin (100，250，500 nM，2 天) 抑制破骨细胞分化中主转录因子 NFATc1 的核转位[2]。Osteostatin (0.1-100 nM, 2 天) 显著促进骨细胞 MC3T3-E1 的生长[3]。 Cell Differentiation Assay[2] Cell Line:
In Vivo	Osteostatin (80 或 120 μg/kg；在疾病发作后每天皮下注射，持续 13 天) 降低关节炎的严重程度及软骨和骨降解[4]。 Animal Model:
Name	Osteostatin
CAS	138949-73-2
Sequence	Thr-Arg-Ser-Ala-Trp
Shortening	TRSAW
Formula	C27H41N9O8
Molar Mass	619.67
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. [2]. Ibáñez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [3]. Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. [4]. Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845.

Tetramethylkaempferol

Valeryl salicylate