| Bioactivity | Oseltamivir-d3 hydrochloride is the deuterium-labeled Oseltamivir (HY-13317)[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| Name | Oseltamivir-d3 hydrochloride |
| Formula | C16H26D3ClN2O4 |
| Molar Mass | 351.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |
Oseltamivir-d3 hydrochloride
CAS: F: C16H26D3ClN2O4 W: 351.88
Oseltamivir-d3 hydrochloride is the deuterium-labeled Oseltamivir (HY-13317). Oseltamivir is an influenza virus neuramin
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