Ortho-hydroxy atorvastatin-d5 calcium_product_DataBase

Bioactivity	Ortho-hydroxy atorvastatin-d5 calciumis the deuterium labeledOrtho-hydroxy atorvastatin(HY-144577)[1]. Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589)[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
Name	Ortho-hydroxy atorvastatin-d5 calcium
CAS	265989-47-7
Formula	C33H30D5FN2O6.1/2Ca
Molar Mass	599.71
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Zhou Y, et al. Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous determination of amlodipine, atorvastatin and its metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin in human plasma and its application in a bioequivalence study. J Pharm Biomed Anal. 2013 Sep;83:101-7.

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