| Bioactivity | Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity[1]. Anti-atherosclerotic effect[2]. | ||||||||||||
| Invitro | Orlistat (40 μM; 2 days) does not affect MGMT levels in a human melanoma cell line, but downregulates the repair protein by 30-70% in human peripheral blood mononuclear cells, in two leukemia and two colon cancer cell lines. Orlistat does not alter noticeably MGMT mRNA expression[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | Orlistat | ||||||||||||
| CAS | 96829-58-2 | ||||||||||||
| Formula | C29H53NO5 | ||||||||||||
| Molar Mass | 495.73 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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