| Bioactivity | Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine[1]. |
| Invitro | Org 43553 (0-3 μM; 4 h) shows agonistic activity to human LH, FSH and TSH receptors[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | Org 43553 (5-50 mg/kg; p.o. once) triggers ovulation in immature mice and increases ovulation in GnRH-antagonist-treated rats[1].Org 43553 (10-250 mg/kg; p.o. once) increases testosterone levels in male rats[1].1.19Pharmacokinetic Properties of Org 43553 in Rats and Dogs[1]. |
| Name | Org 43553 |
| CAS | 501444-88-8 |
| Formula | C24H30N6O3S2 |
| Molar Mass | 514.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. van de Lagemaat R, et al. Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor. Hum Reprod. 2009 Mar;24(3):640-8. |
Org 43553
CAS: 501444-88-8 F: C24H30N6O3S2 W: 514.66
Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 show
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