| Bioactivity | Org-31710 is a specific progesterone receptor (PR) inhibitor. Org-31710 shows antiprogestational effect. Org 31710 abolishes the folic acid (HY-16637)-regulated proliferation and migration in PR positive cancer cell lines. Org 31710 abolishes the folic acid-increased the levels of p-PRA, p-PRB, and p-cSrcY416[1][2]. |
| CAS | 118968-41-5 |
| Formula | C30H39NO2 |
| Molar Mass | 445.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mizutani T, et al. Novel antiprogestins Org 31806 and 31710: interaction with mammalian progesterone receptor and DNA binding of antisteroid receptor complexes. J Steroid Biochem Mol Biol. 1992 Aug;42(7):695-704. [2]. Wang HC, et al. Activation of progesterone receptor is essential for folic acid-regulated cancer cell proliferation and migration. J Nutr Biochem. 2023 Feb;112:109205. |