| Bioactivity | Ophiopogonin B (OP-B) induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1]. |
| Invitro | Ophiopogonin B (0、5、10 和 20μM) 通过 G0/G1 期细胞周期停滞抑制 HT-29 和 HCT-116 细胞系的增殖[1]。Ophiopogonin B 通过抑制 Bax 和裂解 caspase 3 的表达并促进 Bcl-2 的表达来诱导细胞凋亡。Ophiopogonin B 治疗还会增加 Beclin 1 的表达和 LC3I 向 LC3II 的转化，并激活 JNK/c-Jun 信号通路[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ophiopogonin B 相关抗体: |
| CAS | 38971-41-4 |
| Formula | C39H62O12 |
| Molar Mass | 722.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gao GY, et al. Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Biomed Pharmacother. 2018 Dec;108:1208-1215. |
Ophiopogonin B
CAS: 38971-41-4 F: C39H62O12 W: 722.90
Ophiopogonin B (OP-B) induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathwa
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