| Bioactivity | Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research[1][2]. |
| Invitro | Onfekafusp alfa 显示出比 mTNFα 和 TN11mTNFα 更强的抗癌活性[2]。 在 L-M 小鼠成纤维细胞的细胞毒性试验中，Onfekafusp alfa 的活性比等摩尔量的重组 mTNFα 和融合蛋白 TN11mTNFα 高 5 到 6 倍[2]。 |
| Name | Onfekafusp alfa |
| CAS | 1957239-88-1 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Di Giacomo AM, et al. Immunotherapy for brain metastases and primary brain tumors. Eur J Cancer. 2023 Jan;179:113-120. [2]. Borsi L, et al. Selective targeted delivery of TNFalpha to tumor blood vessels. Blood. 2003 Dec 15;102(13):4384-92. |