| Bioactivity | Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp.[1]. | ||||||||||||
| Target | Dihydroorotate dehydrogenase | ||||||||||||
| CAS | 1928707-56-5 | ||||||||||||
| Formula | C28H27FN6O2 | ||||||||||||
| Molar Mass | 498.55 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Lackner M, et al. Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei. J Antimicrob Chemother. 2018 Nov 1;73(11):3068-3073. |
Olorofim
CAS: 1928707-56-5 F: C28H27FN6O2 W: 498.55
Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine bios
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