Bioactivity | Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM[1][2]. | ||||||||||||
Name | Olmesartan methyl ester | ||||||||||||
CAS | 1347262-29-6 | ||||||||||||
Formula | C25H28N6O3 | ||||||||||||
Molar Mass | 460.53 | ||||||||||||
Appearance | Solid | ||||||||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage |
|
||||||||||||
Reference | [1]. Dimitrios Ntountaniotis, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism. Comb Chem High Throughput Screen. 2014;17(8):652-62. [2]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. |