| Bioactivity | Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2]. |
| Invitro | Olanzapine binds weakly to GABAA, Benzodiazepine (BZD), and β-adrenergic receptors (Ki>10 μM) [1][2]. Olanzapine induces autophagy in human SH-SY5Y neuronal cell line[3]. Olanzapine (1-100 μM for 144 h under serum starvation) results in a marked anti-proliferative effect in glioblastoma cell lines as well as glioma stem-like cells[4]. Olanzapine also enhances Temozolomide’s anti-tumor activity in glioblastoma cell lines[4].Olanzapine induces apoptosis and necrosis in glioblastoma cell lines[4]. Cell Proliferation Assay[4] Cell Line: |
| Name | Olanzapine |
| CAS | 132539-06-1 |
| Formula | C17H20N4S |
| Molar Mass | 312.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Olanzapine
CAS: 132539-06-1 F: C17H20N4S W: 312.43
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1,
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