Okadaic acid sodium_product_DataBase

Bioactivity	Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2].
Invitro	Okadaic acid sodium (0-100 nM；24 小时或 48 小时) 抑制 AGS、MNK-45、Caco 2 细胞的增殖[3]。Okadaic acid sodium (10 nM；8 小时) 增加大鼠皮层神经元中的 Drp1 磷酸化和线粒体裂变[4]。 Cell Proliferation Assay[3] Cell Line:
Name	Okadaic acid sodium
CAS	209266-80-8
Formula	C44H67NaO13
Molar Mass	826.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

PeptideDB