| Bioactivity | OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad- |
| Target | IC50: 2.36 nM (Escherichia coli DHFR) |
| Name | OYYF-175 |
| CAS | 65829-22-3 |
| Formula | C17H14FN5 |
| Molar Mass | 307.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yue Li, et al. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur J Med Chem. 2022 Jan 15;228:113979. |