| Bioactivity | OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD)[1]. |
| Invitro | OX01914 (0.1, 10, 40, 50 µM; 24 h) upregulates utrophin mRNA in LUmdx and (30 µM; 24 h) H2K mdx myoblasts[1].OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells[1]. Western Blot Analysis[1] Cell Line: |
| Name | OX01914 |
| CAS | 49676-35-9 |
| Formula | C17H14N4O |
| Molar Mass | 290.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vuorinen A, et al. Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy. Eur J Med Chem. 2021 Aug 5;220:113431. |