| Bioactivity | OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported[1]. |
| Invitro | OUL232 (化合物 27) (1 μM; 10-12 d) 拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡[1]。药代动力学分析[1]water solubility μg/mL |
| Name | OUL232 |
| CAS | 943119-42-4 |
| Formula | C10H10N4O2S |
| Molar Mass | 250.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4. |