| Bioactivity | OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM[1]. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2]. |
| Invitro | OTS964 hydrochloride (10 nM; 48 hours) suppresses cancer cell proliferation[1]. OTS964 hydrochloride (10 nM; 48 hours) increases cancer cell death[1]. OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner[3]. Cell Proliferation Assay[1] Cell Line: |
| Name | OTS964 hydrochloride |
| CAS | 1338545-07-5 |
| Formula | C23H25ClN2O2S |
| Molar Mass | 428.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
OTS964 hydrochloride
CAS: 1338545-07-5 F: C23H25ClN2O2S W: 428.97
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originate
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