| Bioactivity | OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells[1]. OTS514 induces cell cycle arrest and apoptosis[2]. | ||||||||||||
| Invitro | OTS514 (1.5625-100 nM) induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from multiple myeloma (MM) patient-derived peripheral blood mononuclear cells[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | OTS514 | ||||||||||||
| CAS | 1338540-63-8 | ||||||||||||
| Formula | C21H20N2O2S | ||||||||||||
| Molar Mass | 364.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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