| Bioactivity | OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2]. |
| Invitro | OSU-2S (1.25, 2.5 µM; 48 h) 与 Sorafenib (HY-10201) (2.5, 5 µM) 联用时，降低 p-ERK1/2 的表达，增加 PKCδ (38 kDa) 的表达[1]。OSU-2S/Sorafenib (1.25, 2.5 µM; 8 h) 组合抑制细胞增殖和迁移[1]。OSU-2S (0, 1, 2.5, 5 µM; 0-24 h) 以剂量和时间依赖性方式降低 Hep3B 细胞中 PARP 的表达[2]。OSU-2S (5 µM; 12, 24 h) 诱导 Hep3B 细胞凋亡[2]。OSU-2S (0-10 µM; 1 h) 以剂量依赖性方式刺激 Hep3B、Huh7、PLC-5 细胞中 ROS 的产生[2]。 Cell Proliferation Assay[1] Cell Line: |
| Name | OSU-2S |
| CAS | 1351056-65-9 |
| Formula | C21H37NO2 |
| Molar Mass | 335.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |