| Bioactivity | OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells. | ||||||||||||
| Target | EC50: 3 μM (OGT). | ||||||||||||
| Invitro | OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology[1]. | ||||||||||||
| Name | OSMI-4 | ||||||||||||
| CAS | 2260791-14-6 | ||||||||||||
| Formula | C27H26ClN3O7S2 | ||||||||||||
| Molar Mass | 604.09 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. |