| Bioactivity | OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive drug[1]. |
| Target | IC50: 0.6 nM (Kv1.1), 5.4 nM (Kv1.2), 0.014 nM (Kv1.3) and 225 nM (KCa3.1) |
| Invitro | OSK1 has no effect on KCa2.1, KCa2.2, KCa2.3 and KCa1.1 channels when in the micromolar concentration range, whereas it shows a moderate activity on KCa3.1 channel (also referred to as IK1 or SK4) with an IC50 value of 225 nM[1]. |
| In Vivo | OSK1 is lethal in mice by intracerebroventricular injection, with a LD50 (50% lethal dose) value of 2 μg/kg[1]. |
| Name | OSK-1 |
| CAS | 183815-75-0 |
| Formula | C177H300N56O46S8 |
| Molar Mass | 4205.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Stéphanie Mouhat, et al. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. |
OSK-1
CAS: 183815-75-0 F: C177H300N56O46S8 W: 4205.17
OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively.
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