| Bioactivity | OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. | |||||||||
| Target | OSBPL7ABCA1 | |||||||||
| Invitro | OSBPL7-IN-1 (compound G or Cpd G; 1-10 µM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. | |||||||||
| In Vivo | OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1]. Animal Model: | |||||||||
| Name | OSBPL7-IN-1 | |||||||||
| CAS | 1269826-44-9 | |||||||||
| Formula | C20H19Cl2F3N2O3 | |||||||||
| Molar Mass | 463.28 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662. |
OSBPL7-IN-1
CAS: 1269826-44-9 F: C20H19Cl2F3N2O3 W: 463.28
OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of
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