| Bioactivity | ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%). ONO-7579 can be used in cancer research[1]. |
| CAS | 1622212-25-2 |
| Formula | C24H18ClF3N6O4S |
| Molar Mass | 578.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Iida H, et al. Pharmacokinetic-Pharmacodynamic-Efficacy Modeling of ONO-7579, a Novel Pan-Tropomyosin Receptor Kinase Inhibitor, in a Murine Xenograft Tumor Model. J Pharmacol Exp Ther. 2020 Jun;373(3):361-369. |
ONO-7579
CAS: 1622212-25-2 F: C24H18ClF3N6O4S W: 578.95
ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In c
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.