| Bioactivity | ONO-4059 analog is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor. IC50 value: sub-nM range [2]Target: Btkin vitro: ONO-4059 is a selective, once-daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B-cells. ONO-4059 shows a favourable safety profile along with promising efficacy in this difficult-to-treat patient population. [1]in vivo: ONO-4059 has demonstrated anti-tumour activity in several pre-clinical models.[1] ONO-4059 potently and dose-dependently reverse clinical arthritis and prevented bone damage in the CIA model.[2] | ||||||||||||
| Name | ONO-4059 analog | ||||||||||||
| CAS | 1351635-67-0 | ||||||||||||
| Formula | C25H24N6O3 | ||||||||||||
| Molar Mass | 456.50 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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ONO-4059 analog
CAS: 1351635-67-0 F: C25H24N6O3 W: 456.50
ONO-4059 analog is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor. IC50 value: sub-nM r
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