OG-L002 hydrochloride

CAS: 1357299-45-6 F: C15H16ClNO W: 261.75

OG-L002 hydrochloride is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 hydrochloride is

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Bioactivity	OG-L002 hydrochloride is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 hydrochloride is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 hydrochloride potently inhibits the expression of HSV IE genes[1].
Target	IC50 & Target: IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE
Invitro	OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 μM in HeLa cells; IC50: ~3 μM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM)[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> OG-L002 hydrochloride 相关抗体:
In Vivo	OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1].OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1357299-45-6
Formula	C15H16ClNO
Molar Mass	261.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4(1):e00558-12.

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