| Bioactivity | O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1[1]. | ||||||||||||
| Invitro | O4I2 not only promotes Oct3/4 expression by activating its promoter site, but also stabilize the Oct3/4 protein in HEK293 cells[1].O4I2 markedly stimulates Oct3/4 even at 5 µM after 72 hrs treatment on the translationallevel[1].O4I2 (20 µM) accumulates Oct3/4 in NCCIT occurred already 2 hrs after incubation, while the detectable Sox2 increase appears much later, implicating compound-mediated activation of Oct3/4 might be different between embryonic kidney HEK293 cells and embryonal carcinoma NCCIT cells[1]. Immunofluorescence[1] Cell Line: | ||||||||||||
| Name | O4I2 | ||||||||||||
| CAS | 165682-93-9 | ||||||||||||
| Formula | C12H11ClN2O2S | ||||||||||||
| Molar Mass | 282.75 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Cheng X, et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J Med Chem. 2015 Aug 13;58(15):5742-5750. |
O4I2
CAS: 165682-93-9 F: C12H11ClN2O2S W: 282.75
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and
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