Nur77 antagonist 1

CAS: 2378780-25-5 F: C25H32N8OS W: 492.64

Nur77 antagonist 1(Compound ja) is a selective Nur77 antagonist(KDSPRNur77 = 91 nM). Nur77 antagonist 1 induces cancer c

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Nur77 antagonist 1(Compound ja) is a selective Nur77 antagonist(KDSPRNur77 = 91 nM). Nur77 antagonist 1 induces cancer cell apoptosis. ja displays excellent antitumor against triple-negative breast cancer (TNBC) cells[1].
Target	Nur77
Invitro	Nur77 antagonist 1(Compound ja) 对来自不同组织的肿瘤细胞具有选择性，与人类正常乳腺细胞系相比（MCF-10A 的 IC50为48.01 ± 2.86），ja对所有测试的TNBC细胞系（MDA-MB-231, HCC-1806和BT549的IC50分别为0.40 ± 0.03、0.38 ± 0.08和2.12 ± 0.15）具有高度选择性的抗增殖活性[1]。Nur77 antagonist 1 (0-2 μM, 6 h) 以Nur77依赖性方式诱导MDA-MB-231-sictr细胞凋亡[1]。Nur77 antagonist 1 (0-5 μM, 6 h) 通过介导MDA-MB-231细胞中的TP53磷酸化途径，诱导Nur77依赖性细胞周期阻滞和凋亡[1]。 0 --> Nur77 antagonist 1 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Nur77 antagonist 1(Compound ja) (10 mg/kg, 腹腔注射) 在乳腺癌MDA-MB-231异种移植裸鼠模型中具有良好的抗肿瘤效果和良好的体内耐受性[1]。Nur77 antagonist 1 (1.25-5 μM) 在斑马鱼胚胎模型中具有良好的体内安全性[1]。 Animal Model:
Name	Nur77 antagonist 1
CAS	2378780-25-5
Formula	C25H32N8OS
Molar Mass	492.64
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Qin J, et al. Discovery of 5-(Pyrimidin-2-ylamino)-1H-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer. J Med Chem. 2023 Nov 20.