| Bioactivity | Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2]. |
| Invitro | Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines[1].Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells[1].Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells[1].Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively[2]. Cell Viability Assay[1] Cell Line: |
| Name | Nudol |
| CAS | 86630-46-8 |
| Formula | C16H14O4 |
| Molar Mass | 270.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |